Blar i forfatter "Shrestha, Anup"

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    • Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38 MAPK-MK2 axis and affects NF-κB-mediated transcription 

      Shrestha, Anup; Bruckmüller, Henrike; Kildalsen, Hanne; Kaur, Gurjit; Gaestel, Matthias; Ljones Wetting, Hilde; Mikkola, Ingvild; Seternes, Ole Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-09)
      Steroid receptor coactivator-3 (SRC-3) regulates the activity of both nuclear hormone receptors and a number of key transcription factors. It is implicated in the regulation of cell proliferation, inflammation and in the progression of several common cancers including breast, colorectal and lung tumors. Phosphorylation is an important regulatory event controlling the activities of SRC-3. Serine 857 ...

    • The Regulation of Steroid Receptor Co-activator-3 Activity by p38MAPK-MK2 Signaling Pathway 

      Shrestha, Anup (Doctoral thesis; Doktorgradsavhandling, 2022-10-14)
      Steroid receptor co-activator-3 (SRC-3) is a co-activator that plays important roles in normal physiology and different diseases including cancer. Its activity is regulated by phosphorylation. Serine 857 (S857) is the most frequently reported phosphorylation site of SRC-3. In this work, we examined several kinases that could phosphorylate SRC-3 at S857 and explored the functional outcome incurred ...